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04-Apr-2019 00:01

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This design affords the examination of the amount of variability and mutation at each position in the genome for many populations of viruses.This design contains novel visualization techniques that support this specific class of analysis while addressing the issues of data aggregation, confidence visualization, and interaction support that arise when making use of large amounts of sequence data with variable uncertainty.

Multiresolution Correlation Analysis (MCA) is a method for visually identifying subpopulations based on the local pairwise correlation between covariates, without needing to define an a priori interaction scale.Ultimately, the aim is to develop an interactive software application that will allow users to identify, confirm and then remove errors from the pedigree structure and scored genotypes.Layer Cake is a tool designed to assist in the exploration of the genetic variability of the population of viruses at multiple time points and in multiple individuals, a task that necessitates considering large amounts of sequence data and the quality issues inherent in obtaining such data in a practical manner.These techniques generalize to a wide class of visualization problems where confidence is not known a priori, and aggregation in multiple directions is necessary.

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The i HAT prototype tool supports the visualization of multiple sequence alignments, associated metadata, and hierarchical clusterings.MCA thus provides a framework for investigation of expression correlations for genes of interests and biological hypothesis generation.



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